Patients with a body mass index of ≥45 kg/m2 can safely undergo oocyte retrievals and anticipate similar assisted reproductive technology outcomes

 

比較體重指數 (BMI) 為 40-44.9 kg/m² 的患者與 BMI ≥45 kg/m² 的患者 的麻醉和輔助生殖技術 (ART) 結局。

 

l 本研究共納入 98 名 BMI ≥40 kg/m² 且接受取卵的患者：其中 BMI 在 40 至 44.9 kg/m² 之間的患者 56 名，BMI ≥45 kg/m² 的患者 42 名。

 

所有病人均成功接受靜脈鎮靜治療，無需更高程度的鎮靜或照護。

 

BMI ≥45 kg/m² 的患者平均手術時間比 BMI 40-44.9 kg/m² 的患者更長（26.8 分鐘 [標準差，13 分鐘] vs. 22.3 分鐘 [標準差，8.4 分鐘]）。

 

兩組在成熟卵母細胞獲獲數量、第 5/6 天囊胚數、整倍體胚胎數、臨床懷孕率、流產率或活產率均無差異。

 

使用靜脈鎮靜時，BMI ≥45 kg/m² 的患者與 BMI 40-44.9 kg/m² 的患者相比，其輔助生殖技術 (ART) 結局相似，且麻醉或輔助生殖技術併發症較少。

 

在適當的諮詢和術前準備下，BMI ≥45 kg/m² 的患者可以安全地進行取卵。

 

To compare anesthesia and assisted reproductive technology (ART) outcomes in patients with a body mass index (BMI) of 40–44.9 kg/m2 with those with a BMI of ≥45 kg/m2 because these patients are often excluded from care.

 

l           A total of 98 patients with a BMI of ≥40 kg/m2 undergoing oocyte retrieval were identified for the study: 56 patients with a BMI from 40 to 44.9 kg/m2 and 42 patients with a BMI of ≥45 kg/m2.

 

l           Demographics were not statistically significantly different between both groups, except that more patients with a BMI of 40–44.9 kg/m2 identified as White (73% vs. 60%) or Black (9% vs. 0).

 

l           All patients were successfully managed with intravenous sedation and did not require higher level of sedation or care.

 

l           The mean surgical duration was longer in patients with a BMI of ≥45 kg/m2 than in those with a BMI of 40–44.9 kg/m2 (26.8 minutes [standard deviation, 13 minutes] vs. 22.3 minutes [standard deviation, 8.4 minutes]).

 

l          There was no difference in the number of mature oocytes retrieved, day 5/6 blastocysts, the number of euploid embryos, or clinical pregnancy, miscarriage, or live birth rates.

 

l          When using intravenous sedation, patients with a BMI of ≥45 kg/m2 have similar ART outcomes with few anesthesia or ART complications compared with those with a BMI of 40–44.9 kg/m2.

 

l          With appropriate counseling and preoperative preparation, patients with a BMI of ≥45 kg/m2 can safely undergo oocyte retrieval.