粒端telomere 長度 & 粒端酶telomerase活性 與卵子細胞
粒端telomere 長度 & 粒端酶telomerase活性 與卵子細胞 IVF結果關聯性
人類卵母細胞TL在成熟過程中縮短
與其他參數相比，TL 可以更好地預測 IVF 後的結果
卵母細胞 TL vs D3 植入前胚胎的細胞質碎片---負關聯
TL 長度與人類非整倍體異常aneuploid有關
aneuploid囊胚具有更長的TL & 較低TA
TL縮短與卵裂期胚胎的染色體分離錯誤無關
TA 比 TL 更能預測 IVF 治療後的懷孕結局
卵顆粒細胞TA水平可以預測IVF治療的臨床結果
較高的 TA 水準與臨床 IVF 結局呈正相關
卵丘細胞TL 與卵母細胞質量和胚胎發育有關
TL功能和生殖潛力沒有直接關聯，而氧化 DNA 損傷對 IVF 結果和臨床懷孕的早期標記產生不利影響
TL異常與卵巢功能不全有關
卵顆粒細胞 中較低的 TA 和較短的 TL 與 PCOS 和較長的不孕期有關
TA 和 TL 對於 PCOS 患者的胚胎品質和 IVF 結果沒有預後價值
卵巢功能不全患者的顆粒細胞 TA 減少 TL 較短
IVF女性TL 顯著縮短
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224194/
Studies focused on the relation between telomere length/telomerase activity and oocytes
Human oocyte telomeres shorten during maturation
TL provided a better predictor of outcome following IVF than other parameters
Oocyte TL negatively predicted cytoplasmic fragmentation in D3 preimplantation embryos
Telomere DNA length was associated with human aneuploidy development
Aneuploid blastocysts have longer telomeres but lower TA when compared to either euploid or mosaic/segmental human blastocysts
Telomere shortening was not related to chromosome segregation errors in the cleavage stage embryo
TA is a better predictor of pregnancy outcomes following IVF treatment than TL
TA levels in luteinized GCs may predict the clinical outcomes of IVF treatment
Higher TA levels were positively correlated with clinical IVF outcomes
TL in CCs is related to oocyte quality and embryo development
No direct association of telomere function and reproductive potential, while oxidative DNA damage adversely affected early markers of IVF outcome and clinical pregnancies
In young women, abnormal telomere homeostasis is linked to ovarian insufficiency
Lower TA and shorter TL in the GCs were linked with PCOS and a longer period of infertility
No prognostic value for the TA and TL in terms of embryo quality and IVF outcomes in PCOS patients
Shorter LTL and GCTL in women with ovarian insufficiency compared with healthy controls
- Diminished granular cell TA in patients with ovarian insufficiency compared with healthy controls
Women undergoing IVF had statistically significant shorter telomeres compared to healthy controls
Evaluation of telomere length (TL) and telomerase activity (TA) on predicting in vitro fertilization treatment outcomes
