囊胚切片和冷凍之間間隔時間過長會影響胚胎著床率

 

間隔時間超過 1 小時 會顯著影響胚胎存活和臨床結果 

 

 

 

Zygote

. 2021 Aug;29(4):276-281. doi: 10.1017/S0967199420000866. Epub 2021 Feb 18.

 

Prolonged interval time between blastocyst biopsy and vitrification compromised the outcomes in preimplantation genetic testing

These cycles were divided into three groups according to the interval times: <1 h group, 1-2 h group, and ≥2 h group.

In PGT-A cycles, the clinical pregnancy and ongoing pregnancy rates in the <1 h group were 67.44% and 53.49%, respectively, higher than that in the 1-2 h group (52.94%, 47.06%, P > 0.05) and the ≥2 h group (52.63%, 36.84%, P > 0.05). 

In conclusion, vitrification of blastocysts beyond 1 h after biopsy significantly influences embryo survival and clinical outcomes and is therefore not recommended.