使用progestin(PPOS, duphaston 20mg/d) vs GnRH antagonist 應用於試管誘導排卵之LH抑制
|
Variables |
PPOS group (n = 120) |
Antagonist group (n = 120) |
P-value |
|---|---|---|---|
|
Starting dose of FSH (IU) |
225.0 (225.0-225.0) |
225.0 (225.0-225.0) |
0.134 |
|
Total dosage of FSH (IU) |
1800.0 (1575.0-2025.0) |
1800.0 (1575.0-2212.5) |
0.010 |
|
Duration of stimulation (days) |
8.0 (7.0-8.8) |
8.0 (7.0–9.0) |
0.053 |
|
Serum estradiol level on trigger day (pg/ml) |
1870.5 (912.7-2940.1) |
1061.3 (592.0-2614.1) |
0.007 |
|
Serum LH level on trigger day (IU/l) |
4.3 (2.7–5.9) |
2.4 (1.6–3.6) |
0.000 |
|
Serum progesterone level on trigger day (ng/ml) |
0.9 (0.6–1.2) |
0.8 (0.6–1.2) |
0.588 |
|
Premature ovulation (%) |
0.8 (1/120) |
0.8 (1/120) |
1 |
|
No. of retrieved oocytes (n) |
6.0 (3.0–10.0) |
5.0 (3.0–10.0) |
0.914 |
|
No. of mature occytes (n) |
4.5 (2.0–8.0) |
4.0 (3.0–9.0) |
0.980 |
|
No. of oocytes fertilized (n) |
3.0 (2.0–7.0) |
3.0 (2.0–6.0) |
0.728 |
|
Fertilization rate (%) |
94.4 (75.0-100) |
92.9 (75.0-100) |
0.746 |
|
Cleavage rate (%) |
100 (100–100) |
100 (100–100) |
0.648 |
|
No. of blastocysts formation (n) |
1.5 (0–3.0) |
1.0 (0–3.0) |
0.422 |
|
Blastocysts formation rate (%) |
59.4 (33.3–100) |
50.0 (33.3–80) |
0.299 |
|
Total No. of euploid blastocysts |
93 |
97 |
|
|
No. of euploid blastocysts (n) |
0 (0–1.0) |
0 (0–1.0) |
0.995 |
|
Euploid blastocysts rate per injected oocyte (%) |
12.5 (0–25.0) |
16.0 (0-27.7) |
0.477 |
|
Euploid blastocysts rate per woman (%) |
33.3 (0-66.7) |
50.0 (0-66.7) |
0.459 |
|
No. of cycles with no blastocyst for biopsy (%) |
27.5 (33/120) |
30.0 (36/120) |
0.669 |
|
No. of cycles with no euploid blastocysts for transfer (%) |
52.5 (63/120) |
55.0 (66/120) |
0.698 |
|
PPOS group (n = 53) |
Antagonist group (n = 47) |
P-value |
|
|---|---|---|---|
|
Endometrial preparation, n (%) |
0.995 |
||
|
Natural cycles |
1.9 (1/53) |
2.0% (1/47) |
|
|
Clomid-induced |
11.5 (6/53) |
10.0 (5/47) |
|
|
Hormonal cycles |
83.0 (44/53) |
91.5 (43/47) |
|
|
Endometrial thickness (day of trigger) (mm) |
10.0 (8.6–11.0) |
9.1 (8.5–10.4) |
0.600 |
|
hCG test positive rate (%) |
66.0 (35/53) |
70.2 (33/47) |
0.655 |
|
Clinical pregnancy rate (%) |
58.5 (31/53) |
59.6 (28/47) |
0.912 |
|
Clinical miscarriage rate (%) |
9.7 (3/31) |
17.9 (5/28) |
0.359 |
|
Ectopic pregnancy rate (%) |
0 (0/35) |
0 (0/33) |
0 |
|
Live birth rate (%) |
52.8 (28/53) |
48.9 (23/47) |
0.359 |