抗苗勒氏管激素 (AMH) 臨界值以確定多囊性卵巢形態

 

l      評估 AMH 臨界值 3.2 ng/mL 在經陰道超音波 (TVUS) 確定 PCOM 狀態的有效性。

 

l     根據血清AMH或陰道超音波(TVUS)檢測結果，計算PCOM陽性病例（PCOS表型為A、C或D的參與者）和陰性對照的數量。

 

l     3.2 ng/mL為AMH截斷值，   AMH 3.2 ng/m用於檢測PCOM的高準確性。在所有PCOM陽性的PCOS表型和體質指數分類中，AMH與PCOM狀態也具有一致性       

 

Original ArticleVolume 124, Issue 3p543-552  2025/9/162025

Anti-Müllerian hormone cutoff to determine polycystic ovarian morphology: HARMONIA study

 

 

To verify the anti-Müllerian hormone (AMH) cutoff (3.2 ng/mL) for the determination of polycystic ovarian morphology (PCOM) as part of the latest polycystic ovary syndrome (PCOS) diagnosis in an independent prospective cohort of women of reproductive age.

Assessment of the performance of the AMH cutoff of 3.2 ng/mL to identify PCOM status determined by transvaginal ultrasound (TVUS).

The number of PCOM-positive cases (participants with PCOS phenotypes A, C, or D) and negative controls according to serum AMH or TVUS.

Other measures included PCOM status within selected PCOS phenotypes and demographic/clinical factors including body mass index.

Applying the AMH cutoff of 3.2 ng/mL, 118 of 128 cases and 639 of 820 controls were identified in accordance with TVUS (overall percent agreement, 79.9%).

Agreement of AMH with PCOM status was also observed across all PCOM-positive PCOS phenotypes and body mass index categories.

Conclusion

The Elecsys AMH Plus immunoassay cutoff of 3.2 ng/mL was successfully verified, showing high accuracy to detect PCOM.

 On the basis of current guideline recommendations for the detection of PCOM as part of PCOS diagnosis, these data support use of the AMH test as an easy-access diagnostic workup tool compared with TVUS.